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血清和精液中广生多种抗体能致男性免疫性不育症精子和精浆均存在多种抗原物质,人体有两种功能可防止产生对抗这些物质的抗体:①“血—精液”屏障:男生殖管道全长均存在这种屏障,它不仅能阻止抗体由血循环进入精液内,还可阻止精液抗原进入体循环内。②精液的免疫抑制作用:精子和精浆均可抑制周围血淋巴细胞的母细胞化,即使精液外漏,亦可有效地阻止抗体的产生.只有在异常情况下精子抗体才可产生。自1954年以来,学者们在一些男性的血和精浆内发现多种抗精子抗体,其中精子凝集抗体、制动抗体和细胞毒抗体能对抗精子表面抗原,有可能导致不育.
There are two kinds of antigenic substances in sperm and seminal plasma of male immune sterility. There are two kinds of functions in the body to prevent the production of antibodies against these substances: ① “blood-semen” barrier: Male reproductive tract length of the existence of this barrier, it not only prevents the antibody from entering the blood circulation into the semen, but also prevent the semen antigen into the systemic circulation. ② semen immunosuppression: sperm and seminal plasma can inhibit the peripheral blood lymphocytes of the mother cell, even if the semen leakage, but also effectively prevent the production of antibodies only in abnormal cases can produce sperm antibodies. Since 1954, scholars have found a variety of anti-sperm antibodies in blood and seminal plasma of some men. Among them, sperm agglutination antibodies, brake antibodies and cytotoxic antibodies can antagonize sperm surface antigens and may lead to infertility.