Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants

• 作 者: Ye Liu Yinyu Wang Fangfang Wan
• 机 构: TheInternationalPeaceMaternityandChildHealthHospital,TheKeyLaboratoryofReproductiveGenetics（Ministry
• 出 处: 中国科学:生命科学英文版
• 发表日期: 2019年2期
• 关键词: ANDROGEN receptor SPLICE variants nuclear TRANSLOCATION heat shock protein 90 IM
• 基金项目: supported by the National Key Research and Development Program of China (2017YFC1001303),International Cooperation Project of China and Canada NSFC (81661128010),National Natural Science Foundation of

As shown in our previous study, two alternatively spliced androgen receptor(AR) variants, which are exclusively expressed in the granulosa cells of patients with polycystic ovary syndrome, exhibit retarded nuclear translocation compared with wild-type AR.