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Numerous studies have indicated oxidative stress as a key pathological factor in ischemic brain injury.One of the key li......
Relationship between gene expression of nitric oxide synthase and androgens in rat corpus cavernosum
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Effects of competitive and noncompetitive 5α-reductase inhibitors on serum and intra-prostatic andro
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Treatment of Severe Aplastic Anemia by Immunosuppressor Anti-lymphocyte Globulin/Anti-thymus Globuli
Objective:To study the therapeutic effect of combined therapy with Chinese drugs and immunosuppressors, mainly anti-lymp......
目的验证Stock等切除睾丸和嗅球建立的大鼠模型是否可成为模拟老年男性抑郁症的一种实验动物模型。方法按随机数字表法，将健康成年......
前列腺癌组织中除肿瘤细胞外还存在多种大量炎性细胞，如肥大细胞、巨噬细胞、中性粒细胞等，这些炎性细胞可分泌多种细胞因子，促进炎性......
目的 探讨胚胎期雄激素受体阻滞剂氟他胺(flutamide,Flu)暴露对睾丸间隙连接蛋白43 (Connexin43,Cox43)基因表达的影响.方法 在胚......
目的 通过研究睾丸和睾丸引带组织雄激素受体(androgen receptor,AR)的表达情况,以进一步探讨小鼠睾丸引带发育与睾丸下降发育的关......
目的 探讨雄激素受体(AR)基因第1外显子三核苷酸胞嘧啶-腺嘌呤-鸟嘌呤基因重复序列[(CAG)n]多态性在绝经后骨质疏松(PMO)发生中的......
目的 了解雄激素及其受体与盆底功能障碍性疾病的关系.方法 对象为盆底器官脱垂性疾病行子宫切除术患者38例和非盆底器官脱垂件疾......
目的 探讨三螺旋形成寡核苷酸(TFO)和反义寡核苷酸(ASO)对人前列腺癌裸鼠移植瘤雄激素受体(AR)表达和肿瘤细胞生长的抑制作用.方法......
目的 探讨人雄激素受体基因第一外显子CAG重复序列长度多态性与痤疮发生之间的关系.方法 研究对象为中国东北地区238例痤疮患者和2......
Objective: To explore the characteristics of bone mineral density (BMD) and treatment in Chinese patients with complete ......
Aim: To investigate the androgen receptor (AR) isoform expressions in human prostatic cancer tissue and LNCaPcell line.......
The quantitative structure-activity relationship (QSAR) of 14 phenoxybenzoic acid derivatives was studied by ab initio m......
前列腺癌(prostatic cancer,PCa)是男性生殖系最常见的恶性肿瘤,其发病率随年龄而增长,且有明显的地区差异,欧美地区较高。在中国,......
前列腺癌(prostate cancer,PCa)是欧美男性中常见的肿瘤,近年来其在中国的发病率成上升趋势。去势抵抗前列腺癌(castration-resist......
[目的]探讨雄激素受体(androgen receptor,AR)在人表皮生长因子受体-2(human epidermal growth factor receptor-2,Her-2)过表达型......
目的 观察老年男性冠状动脉粥样硬化性心脏病(冠心病)患者性激素及雄激素受体水平的变化及相关性. 方法 横断面调查老年男性539例,......
Relationship between gene expression of nitric oxide synthase and androgens in rat corpus cavernosum
Objective To cladfy the dependence of neural nitric rnoxide synthase mRNA (nNOSmRNA) and endothelial rnnitric oxide syn......
Effects of competitive and noncompetitive 5α-reductase inhibitors on serum and intra-prostatic andro
Background 5α-Reductase inhibitors (5α-RI) act by inhibiting the conversion of testosterone to dihydrotestosterone (DH......
Bcl-2 expression is a poor predictor for hepatocellular carcinoma prognosis of andropause-age patien
Objective: The expression of B-cell lymphoma 2(Bcl-2) seems to be influenced by the endocrine environment. Numerous repo......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
[目的]探讨雄激素受体(AR)、人体抑癌基因p53在三阴性乳腺癌(triple-negative breast cancer,TNBC)中的表达及其意义.[方法]收集20......
Relationship of level of sex hormone and sex hormone receptor with development of metabolic syndrome
Objective The sex hormone and the corresponding receptor may play some roles in the development of the metabolic syndrom......
目的 通过地塞米松体外诱导卵巢器宫胰岛素抵抗,探讨隐丹参酮对糖代谢、激素以及卵巢信号分子的影响.方法 40只18 g清洁级昆明白雌......
Objective To investigate the variation of sex hormone and its receptor level in elderly male patients with coronary hear......
目的 进一步验证前列腺癌雄激素阻断治疗与骨质疏松的关系,对阿仑膦酸防治由前列腺癌雄激素阻断治疗所引起骨质流失的作用进行评估......
Aim: To study theapoptotic rate (AR) and the androgen and estrogen milieu in the proximal and distal ductal sys tems of ......
目的 利用Forskolin分别对正常卵巢颗粒细胞和胰岛素抵抗卵巢颗粒细胞进行刺激,观察两组细胞刺激前后生物学效应变化的差异.方法 ......
Studies on Androgen Receptor mRNA expression in Pancreas, Hypothalamus and Ovary of Androgen Sterili
Objective To investigate the androgen receptor (AR) mRNA expression in pancreas,hypothalamus and ovary of androgen steri......
Objective:To study the etiology and differential diagnosis of ambiguous genitalia.Methods:One hundred and five cases of......
雄激素可以介导大量的生理反应,其作用是通过雄激素受体实现的.雄激素受体分为细胞内受体和膜受体.细胞内受体属于核受体家族,有3......
在肝脏组织癌变过程中,雄激素及其受体可能起到重要作用.相关研究证实大多数肝细胞癌患者癌组织中都能检测到雄激素受体的表达,且......
目的 观察睾丸酮对MCF-7乳腺癌细胞株增殖、凋亡的影响,并探讨其机制.方法 将1×10~(-5)、1×10~(-7)、1×10~(-9)、1×10~(-11) m......
With the extensive utilization of PSA,digital rectum examination and transrectal ultrasound for screening in the aging p......
目的 探讨雄激素对HIBD新生大鼠脑保护作用及量效关系,初步揭示雄激素的远期副作用.方法 3日龄SD大鼠72只随机分为:假手术组(n=8)......
目的 通过观察选择性雄激素受体调节剂对迟发性腺功能减退大鼠的作用,为治疗LOH提供理论依据.方法 将30只符合标准的老年Wistar大......
目的：探讨siRNA干扰雄激素受体相互作用蛋白HSPBAP1对前列腺癌PC3恶性表型的影响。方法 siRNA干扰PC3细胞HSPBAP1的表达，检测细胞增......
目的建立糖尿病性勃起功能障碍(DMED)大鼠模型,评价雄激素联合5型磷酸二酯酶抑制剂对DMED的治疗作用。方法通过链脲佐菌素(STZ)腹......
雄激素控制着广泛的生理学功能.雄激素受体作为调节雄激素多种生物学作用的甾体类受体,是一种配基诱导的转录因子.雄激素信号系统......
AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprote......
目的：剂量敏感的性别反转-先天性肾上腺发育不良基因1（dosage-sensitive sex reversal, adrenal hypoplasia critical region, on ch......
The purpose of this study was to develop a protein chip technique based on receptor binding assays to measure bioavailab......
前列腺癌是男性泌尿系统的恶性肿瘤,超过70%的患者会发生骨转移,其主要治疗手段就是雄激素剥夺疗法,随着病情的发展,最终多数会转......
目的 探讨老年男性颈动脉内膜中层厚度与雄激素和雄激素受体水平变化的相关性. 方法 入组老年男性89例,根据颈动脉内膜中层厚度分......
