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目的探讨TIA患者颈总动脉内中膜厚度(CCA-IMT)与颅外血管事件和脑卒中复发的相关性。方法研究共纳入212名TIA患者,采集患者一般情况资料、临床特征和疾病情况,进行头部CT检查和颈动脉超声检测,分析CCA-IMT与TIA风险因素的相关性;对患者进行为期1年的随访观察,分析CCA-IMT与颅外血管事件以及脑卒中复发的预测效应。结果共发生24例颅外血管事件(18例冠心病和6例外周血管病)和16例脑卒中复发。CCA-IMT与TIA多种风险因素相关,男性年龄>60岁以及具有高血压、冠心病患病史的患者中CCA-IMT显著增加。生存分析结果 CCA-IMT对颅外血管事件具有良好的预测效应,CCA-IMT值>0.939mm患者颅外血管事件风险显著增加(P=0.000)。结论 CCA-IMT较高TIA患者颅外血管事件风险增加,CCA-IMT对TIA患者颅外血管事件具有良好的预测作用,可作为临床上常用的预测手段。
Objective To investigate the relationship between carotid intima-media thickness (CCA-IMT) and extracranial vascular events and recurrent stroke in patients with TIA. METHODS: A total of 212 TIA patients were enrolled in this study. General information, clinical features and disease status of the patients were collected. Head CT and carotid ultrasonography were performed to analyze the correlation between CCA-IMT and TIA risk factors. Patients were followed up for 1 year The follow-up observation, analysis of CCA-IMT and extracranial vascular events and prediction of the impact of recurrent stroke. Results A total of 24 cases of extracranial vascular events (18 cases of coronary heart disease and 6 cases of peripheral vascular disease) and 16 cases of recurrent stroke. CCA-IMT is associated with a number of risk factors for TIA, with significant increases in CCA-IMT among men> 60 years of age and those with a history of hypertension and coronary heart disease. Survival analysis showed that CCA-IMT had a good predictive value for extracranial vascular events. The risk of extracranial vascular events was significantly increased in patients with CCA-IMT> 0.939 mm (P = 0.000). Conclusion CCA-IMT higher TIA patients with increased risk of extracranial vascular events, CCA-IMT TIA patients with extracranial vascular events have a good predictive effect, can be used as a clinical prediction.