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目的:探究奥美拉唑与奥曲肽联合治疗肝炎后肝硬化合并上消化道出血的临床效果。方法:将我院64例肝炎后肝硬化合并上消化道出血患者随机分为对照组(n=32)与实验组(n=32),对照组采用垂体后叶素+奥美拉唑治疗;实验组采用奥曲肽+奥美拉唑治疗,比较两组临床治疗效果。结果:实验组治疗总有效率为90.63%,显著高于对照组71.88%(p<0.05);实验组平均止血时间(18.05±1.19)h,明显短于对照组(27.93±2.06)h,差异有统计学意义(p<0.05);实验组用药后不良反应几率6.25%,显著低于对照组15.63%(p<0.05)。结论:联合应用奥美拉唑、奥曲肽治疗肝炎后肝硬化合并上消化道出血疗效确切,可快速止血,且不良反应少,值得推广。
Objective: To investigate the clinical effect of omeprazole combined with octreotide in the treatment of posthepatitic cirrhosis with upper gastrointestinal hemorrhage. Methods: Sixty-four patients with posthepatitic cirrhosis and upper gastrointestinal hemorrhage were randomly divided into control group (n = 32) and experimental group (n = 32), and control group received pituitrin plus omeprazole. The experimental group was treated with octreotide plus omeprazole, and the clinical effects of the two groups were compared. Results: The total effective rate of the experimental group was 90.63%, significantly higher than that of the control group (71.88%, p <0.05). The average bleeding time of the experimental group was (18.05 ± 1.19) h, which was significantly shorter than that of the control group (27.93 ± 2.06) h, (P <0.05). The incidence of adverse reactions in the experimental group was 6.25%, which was significantly lower than that in the control group (15.63%, p <0.05). Conclusion: Combined use of omeprazole and octreotide is effective in treating posthepatitic cirrhosis with upper gastrointestinal hemorrhage. Hemostasis can be quickly stopped with fewer side effects. It is worth promoting.