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近年来,随着广谱抗生素、激素和免疫抑制剂的应用,新型隐球菌引起的病例也逐渐增多。1998年2月,我们从一患者的脑脊液、血液、痰及尿标本中同时分离出一株新型隐球菌,报告如下。 患者,男,52岁。在患脑膜炎前半个月,发现胸背部有带状皮疹,在当地医院拟诊为带状疱疹,经青霉素、病毒唑治疗10d,病情有所好转。7d后,患者有发热、头痛伴呕吐,并逐渐加重而转入我院。查体:T39.5℃,颈强直,克氏、布氏征(+)。外周血WBC18.4×10~9/L,N0.93,L0.07,ALT143.6U/L。脑脊液检查:无色透明,WBC192×10~6/L,多核细胞0.35,单核细胞0.65,潘氏试验(+),糖2.24mmol/L。 真菌学检查:血液经增菌2d发现浑浊,转种血平板。脑脊液、痰、尿标本直接种血平板上,经37℃24h在血平板上长
In recent years, with the application of broad-spectrum antibiotics, hormones and immunosuppressive agents, the incidence of Cryptococcus neoformans has also gradually increased. In February 1998, we isolated a new type of Cryptococcus neoformans from the cerebrospinal fluid, blood, sputum and urine of a patient. The report is as follows. Patient, male, 52 years old. In the first half of meningitis, found a chest strip of rash on the back, in the local hospital to be diagnosed as shingles, penicillin, ribavirin treatment 10d, the condition has improved. After 7 days, the patient had fever, headache and vomiting, and gradually increased and transferred to our hospital. Physical examination: T39.5 ℃, neck stiffness, Kirschner, Buchner sign (+). Peripheral blood WBC18.4 × 10 ~ 9 / L, N0.93, L0.07, ALT143.6U / L. Cerebrospinal fluid examination: colorless and transparent, WBC192 × 10 ~ 6 / L, mononuclear cells 0.35, monocytes 0.65, Pan’s test (+), sugar 2.24mmol / L. Mycology check: blood turbid 2d by bacteria, seeded blood plate. Cerebrospinal fluid, sputum and urine samples were directly seeded on the blood plate and grown on the blood plate for 24 hours at 37 ° C