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文献报道强力霉素单剂治疗流行性斑疹伤寒可获良好疗效,但强力霉素单剂治疗地方性(鼠型)斑疹伤寒则尚无专门研究。我们从1981年10月至1983年2月,以强力霉索单剂治疗地方性斑疹伤寒进行了临床研究,并取得了较好疗效,现报道如下。一、诊断标准及治疗分组 (一)诊断标准:(1)有发热、头痛、皮疹及肝脾肿大等症状及体征;(2)外斐氏反应Ox_(19)效价1:160以上,复查无递减或恢复期较急性期效价升高4倍以上者;(3)斑疹伤寒分型补体结合试验:莫氏效价1:40以上,并且效价大于普氏2个滴度以上或普氏效价1:40以下者。 (二)分组治疗:凡入院时符合上述3条诊断标准的地方性斑疹伤寒患者,皆按入院顺序随机分组治疗。(1)强力霉素单剂治疗组:强力霉毒0.2g,入院后顿服,共101例。(2)土霉素治疗组(对照组):土霉素0.5g,1日4次口服,连用5天,共85例。
Reported in the literature doxycycline monotherapy for epidemic typhus can be a good effect, but doxycycline single treatment of endemic (murine) typhus is still no special study. From October 1981 to February 1983, we conducted a clinical study with endemic mycotoxins to treat endemic typhus and achieved good results. The results are reported below. First, the diagnostic criteria and treatment group (a) the diagnostic criteria: (1) fever, headache, rash and hepatosplenomegaly and other symptoms and signs; (2) outside the Peijier reaction Ox_ (19) titer of 1: Review no reduction or recovery period more than 4 times the acute phase of the titers; (3) typhus type complement complement test: Mohs titer 1:40 or more, and the titers greater than Platts 2 titers above Or Platts potency 1:40 the following. (B) group therapy: Where to meet the above three diagnostic criteria of endemic typhus patients, according to the order of admission randomized treatment. (1) Doxycycline single-agent treatment group: Toxoplasma gondii 0.2g, Dayton after admission, a total of 101 cases. (2) oxytetracycline treatment group (control group): oxytetracycline 0.5g, 4 times a day orally, once every 5 days, a total of 85 cases.