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为解决创伤修复过程中致病菌引起的感染问题,本研究制备了γ-聚谷氨酸/壳聚糖/纳米银复合水凝胶,对复合材料进行结构性能、物理性能、细胞毒性和抗菌性评价。透射电子显微镜结果表明,材料上合成粒径1~9nm的纳米银粒子;扫描电子显微镜观察到材料呈三维网状结构,傅里叶红外光谱表明,原位合成纳米银的化学反应不影响水凝胶的化学结构;热失重分析表明,材料具有良好的热稳定性且可以通过调整反应物剂量调控纳米银在水凝胶上的负载量;细胞毒性实验和抗感染实验证明复合水凝胶具有良好的细胞相容性和抗菌性。本研究为实现基于纳米银的抗菌性创伤修复材料的应用奠定实验基础。
In order to solve the problem of infection caused by pathogenic bacteria during wound healing, γ-polyglutamic acid / chitosan / nano-silver composite hydrogels were prepared in this study. Their structural properties, physical properties, cytotoxicity and antibacterial activity Sexual evaluation. Transmission electron microscopy results showed that nano-silver particles with particle size of 1 ~ 9nm were synthesized on the materials. Three-dimensional network structure was observed by scanning electron microscopy. Fourier transform infrared spectroscopy showed that the chemical reaction of nano-silver synthesized in situ did not affect the hydration The chemical structure of the gel shows that the material has good thermal stability and the loading of the nano-silver on the hydrogel can be regulated by adjusting the dose of the reactant. Cytotoxicity experiments and anti-infective experiments show that the composite hydrogel has good thermal stability Cell compatibility and antibacterial properties. This study laid the experimental foundation for the application of nano silver-based anti-bacterial wound repair materials.