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作者研究了不同水平浓缩铀（ＵＯ２Ｆ２）内污染机体后。对中枢和外周免疫活性细胞ＤＮＡ合成的刺激作用与免疫毒理效应．结果发现，当浓缩铀摄入量为１０～５００μｇ／ｋｇ体重时，脾Ｔ、Ｂ淋巴细胞和胸腺淋巴细胞３Ｈ－ＴｄＲ掺入显著降低（Ｐ＜０．０５或Ｐ＜０．０１），其ＤＮＡ合成呈现明显抑制效应．然而，当浓缩铀摄入量为０．１μｇ／ｋｇ体重时，脾ＰＨＡ反应性Ｔ淋巴细胞３Ｈ－ＴｄＲ掺入显著高于对照组（Ｐ＜０．０５），其ＤＮＡ合成呈现明显的刺激作用．诱发细胞增殖刺激作用的浓缩铀剂量与不同免疫活性细胞的辐射敏感性有关．应用数学方法拟合出不同免疫活性细胞的剂量效应曲线方程，呈直线平方模型．浓缩铀内污染１４天后，各免疫活性细胞３Ｈ－ＴｄＲ掺入率未见恢复正常．
The authors studied the contamination of organisms within different levels of enriched uranium (UO2F2). Stimulation and immunotoxicological effects on DNA synthesis in central and peripheral immunocompetent cells. The results showed that incorporation of 3H-TdR in spleen T, B lymphocytes and thymus lymphocytes was significantly decreased (P <0.05 or P <0.01) when uranium enrichment was 10 ~ 500μg / kg body weight, DNA synthesis showed a significant inhibitory effect. However, 3H-TdR incorporation in splenic PHA-reactive T lymphocytes was significantly higher than that of the control group (P <0.05) when the uranium intake was 0.1 μg / kg body weight and the DNA synthesis was significantly stimulated . The dose of enriched uranium that induces cell proliferation stimuli is related to the radiosensitivity of different immunocompetent cells. The dose-response curve equations of different immunocompetent cells were fitted by mathematical method and presented as a linear square model. 3H-TdR incorporation rate of various immunocompetent cells did not return to normal after 14 days of contamination in enriched uranium.