论文部分内容阅读
目的:探讨盐敏感性高血压患者血清非对称二甲基精氨酸(ADMA)的关联。方法:选择广州市南沙区榄核医院、广州市番禺区新造医院、广州市南沙区妇幼保健院2015年9月至2016年10月收治的高血压患者600例,根据WHO/ⅠSH的分级标准,分级如下:Ⅰ级病例200例,Ⅱ级病例250例,Ⅲ级病例150例。同时选择广州市南沙区榄核医院同期健康体检者600例作为对照组,比较两组血清ADMA和一氧化氮(NO)水平。结果:(1)观察组血清ADMA水平明显更高,NO水平明显更低,组间比较,差异具有统计学意义(P<0.05)。(2)盐敏感性高血压患者的血清ADMA水平明显高于对照组,NO水平明显低于对照组,组间比较,差异具有统计学意义(P<0.05)。Ⅰ级和Ⅱ级、Ⅲ级对比,Ⅱ级和Ⅲ级的血清ADMA水平明显高于Ⅰ级,NO水平明显低于Ⅰ级,组间比较,差异具有统计学意义(P<0.05)。Ⅱ级和Ⅲ级对比,Ⅲ级的血清ADMA水平明显高于Ⅱ级,NO水平明显低于Ⅱ级,组间比较,差异具有统计学意义(P<0.05)。(3)高血压组ADMA水平和血压血脂的关系为显著正相关。结论:血清ADMA在盐敏感性高血压的发病发展中发挥着重要的作用,二者密切相关,对血清ADMA进行测定,有利于判定盐敏感性高血压的病情程度。
Objective: To investigate the association of serum asymmetric dimethylarginine (ADMA) in patients with salt-sensitive hypertension. Methods: Six hundred and sixty hypertensive patients admitted from November 2015 to October 2016 in Lancun Hospital of Nansha District, Guangzhou City, Panyu District, Guangzhou City, Maternal and Child Health Hospital of Guangzhou City were selected. According to WHO / ⅠSH grading standards, The grading was as follows: 200 cases of grade Ⅰ, 250 cases of grade Ⅱ and 150 cases of grade Ⅲ. At the same time, we selected 600 healthy subjects in Lancun Hospital of Guangzhou City during the same period as the control group, and compared the serum levels of ADMA and nitric oxide (NO). Results: (1) The level of serum ADMA in the observation group was significantly higher and the level of NO was significantly lower. There was significant difference between the two groups (P <0.05). (2) The level of serum ADMA in patients with salt-sensitive hypertension was significantly higher than that in the control group, and the level of NO was significantly lower than that in the control group. There was significant difference between the two groups (P <0.05). The levels of ADMA in grade Ⅰ and Ⅱ, Ⅲ were significantly higher than those in grade Ⅰ and Ⅱ, and the level of NO in grade Ⅱ and Ⅲ was significantly lower than that in grade Ⅰ. The difference was statistically significant (P <0.05). The level of ADMA in grade Ⅲ was significantly higher than that in grade Ⅱ, and the level of NO in grade Ⅲ was significantly lower than that in grade Ⅱ. The difference was statistically significant (P <0.05). (3) There was a significant positive correlation between ADMA level and blood pressure and blood lipid in hypertension group. Conclusion: Serum ADMA plays an important role in the pathogenesis of salt-sensitive hypertension. The two are closely related to each other. Determining serum ADMA is helpful to determine the severity of salt-sensitive hypertension.