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目的:了解G6PD缺乏新生儿的血胆红素动态变化特点,指导其诊断和治疗。方法:采用微量胆红素法对出生的44例G6PD缺乏新生儿进行出生24 h内～144 h血胆红素监测并将其结果进行统计分析。结果:G6PD缺乏患儿出生～24 h、～48 h、～72 h、～96 h、～120 h、～144 h的血胆红素分别为(94.73±31.43)μmol/L、(171.36±44.08)μmol/L、(222.53±50.35)μmol/L、(222.8±46.79)μmol/L、(206.43±52.98)μmol/L、(186.38±52.98)μmol/L,与正常足月新生儿相比较差异有统计学意义(P<0.05)。结论:G6PD缺乏患儿24 h内～144 h血胆红素浓度明显高于正常的生理性黄疸,动态监测新生儿血胆红素可早期发现、及时治疗由于G6PD缺乏导致的高胆红素血症,以防止高胆红素血症后遗症的发生。
Objective: To understand the dynamic changes of serum bilirubin in neonates with G6PD deficiency and to guide their diagnosis and treatment. Methods: 44 cases of G6PD-deficient newborns born within 24 hours after birth were monitored by micro-bilirubin method for 144 hours. Serum bilirubin was monitored and the results were statistically analyzed. Results: The serum levels of bilirubin in children with G6PD deficiency at 24 h, 48 h, 72 h, 96 h, 120 h, and 144 h were (94.73 ± 31.43) μmol / L, 171.36 ± 44.08 (222.53 ± 50.35) μmol / L, (222.8 ± 46.79) μmol / L, (206.43 ± 52.98) μmol / L and (186.38 ± 52.98) μmol / L, respectively) There was statistical significance (P <0.05). Conclusion: The level of serum bilirubin in children with G6PD deficiency within 24 hours is significantly higher than that of normal physiological jaundice. The dynamic monitoring of neonatal bilirubin can be detected early and timely treatment of hyperbilirubinemia due to G6PD deficiency Symptoms to prevent the occurrence of hyperbilirubinemia sequelae.