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目的:观察补充小剂量L-甲状腺素对早产儿暂时性低甲状腺素血症的近期疗效及安全性。方法:将符合条件的63例早产低甲状腺素血症儿分为治疗组32例和对照组31例,治疗组给予小剂量L-甲状腺素片口服,观察两组在静脉营养、光疗、住院时间、恢复出生体重、消化异常、心率及颅内异常发生率等方面差异,比较治疗组在治疗前后血生化方面改变。结果:治疗组静脉营养、光疗、恢复出生体重及住院时间比对照组明显缩短(P<0.05),消化系统异常天数减少(P<0.01),心率无明显增快(P>0.05),颅内出血及脑白质病发生率无增加(P>0.05)。治疗组在治疗前后血谷丙转氨酶、肌酐、尿素氮、前白蛋白、心肌酶及血糖无明显变化(P>0.05)。结论:早期小剂量补充甲状腺素安全有效,可以提高患儿早期生活质量,减少家长经济负担。
Objective: To observe the short-term efficacy and safety of low-dose L-thyroxine in the treatment of transient hypothyroxinemia in premature infants. Methods: A total of 63 preterm hypothyroxinemia patients were divided into treatment group (32 cases) and control group (31 cases). The treatment group was given low dose of L-thyroxine tablets orally. The effects of intravenous nutrition, phototherapy, hospital stay , To restore birth weight, digestive abnormalities, heart rate and the incidence of intracranial abnormalities and other differences between the treatment group before and after treatment in the blood biochemical aspects of change. Results: The veins nutrition, phototherapy, birth weight recovery and hospital stay in the treatment group were significantly shorter than those in the control group (P <0.05). The days of abnormal digestive system were decreased (P <0.01) And no increase in the incidence of leukoencephalopathy (P> 0.05). Before and after treatment in the treatment group, blood alanine aminotransferase, creatinine, urea nitrogen, prealbumin, myocardial enzymes and blood glucose did not change significantly (P> 0.05). Conclusions: Early low-dose thyroxine supplementation is safe and effective, which can improve early life quality and reduce economic burden on parents.