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目的了解南宁地区孕妇、胎儿与新生儿TORCH感染情况及与不良妊娠和新生儿疾病的关系。方法对2008年1月—2013年12月在广西壮族自治区妇幼保健院就诊的39 281例孕妇、18 757例新生儿外周血和4 833例孕妇产前脐血采用酶联免疫吸附方法检测血清TORCH抗体并收集孕妇和新生儿临床诊断信息,分析不良妊娠组、正常妊娠组脐血及各种新生儿疾病中TORCH-Ig M阳性率。结果 39 281例孕妇、4 833例产前脐血和18757例新生儿TORCH-Ig M总阳性率分别为2.86%、0.89%和1.60%,其中均以CMV-Ig M阳性率最高,分别为0.88%、0.34%和1.31%。不良妊娠组和正常妊娠组脐血TORCH-Ig M总阳性率分别为1.44%和0.45%,2组比较差异有统计学意义(P<0.05);新生儿肝炎综合征、病理性黄疸、败血症和肺炎患儿中TORCH-Ig M阳性率较高,依次为18.75%、2.74%、1.93%和1.64%。结论 CMV是南宁地区孕妇与新生儿感染的主要TORCH病原体,且与新生儿肝炎综合征、病理性黄疸等疾病呈正相关,有必要进行TORCH筛查。
Objective To investigate the relationship between TORCH infection in pregnant women, fetuses and neonates and their relationship with adverse pregnancy and neonatal diseases in Nanning. Methods From January 2008 to December 2013, 39 281 pregnant women, 18 757 neonates and 4833 pregnant women with prenatal umbilical cord blood from the MCH hospital of Guangxi Zhuang Autonomous Region were tested for serum TORCH by enzyme-linked immunosorbent assay Antibodies and collect clinical diagnostic information of pregnant women and newborns, analysis of TORCH-Ig M positive rate in poor pregnancy group, normal pregnancy group cord blood and various neonatal diseases. Results The positive rates of TORCH-Ig M in 39,281 pregnant women, 4,833 prenatal umbilical cord blood and 18,757 newborns were 2.86%, 0.89% and 1.60%, respectively, of which the positive rates of CMV-Ig M were the highest %, 0.34% and 1.31%. The positive rates of TORCH-Ig M in cord blood of adverse pregnancy group and normal pregnancy group were 1.44% and 0.45% respectively, there was significant difference between the two groups (P <0.05); neonatal hepatitis syndrome, pathological jaundice, sepsis and The positive rate of TORCH-Ig M in children with pneumonia was higher, followed by 18.75%, 2.74%, 1.93% and 1.64%. Conclusion CMV is the main TORCH pathogen of infection in pregnant women and newborns in Nanning. It is positively correlated with neonatal hepatitis syndrome and pathological jaundice, and it is necessary to screen for TORCH.