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目的观察糖尿病患者绝经前后血清脂蛋白〔LP(a)〕及血脂含量变化。方法糖尿病患者69例均为女性,分为绝经前组、绝经后组。测定晨起空腹静脉血中脂蛋白〔LP(a)〕、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C),将各指标与健康对照组、糖尿病绝经前、绝经后组比较。结果糖尿病组LP(a)、TC、TG、LDL-C均高于对照组,HDL-C、HDL-C/TC低于对照组,绝经后组LP(a)、TC、HDL-C高于绝经前组,HDL/TC低于绝经前组。结论女性糖尿病患者绝经后血清LP(a)、TC、LDL-C增高,HDL-C/TC较绝经前降低。
Objective To observe the changes of serum lipoprotein (LP) and blood lipid in patients with diabetes before and after menopause. Methods 69 cases of diabetic patients were female, divided into premenopausal group, postmenopausal group. The levels of lipoprotein (LP), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL- , The indicators and healthy control group, pre-diabetic menopause, postmenopausal group comparison. Results The levels of LP (a), TC, TG and LDL-C in diabetic group were significantly higher than those in control group, while the levels of HDL-C and HDL-C / TC in control group were lower than those in control group Premenopausal group, HDL / TC lower than the premenopausal group. Conclusion The serum levels of LP (a), TC, LDL-C in postmenopausal women with diabetes mellitus are increased, and HDL-C / TC is lower than that in premenopausal women.