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目的 检测33例经病理检查证实胃肠道恶性肿瘤患者血清NO、LPO、SOD水平。结果与慢性浅表性胃炎组相比，恶性肿瘤患者NO水平显著低下（P＜0．05），LPO水平显著增高（P〈0．01）；其总SOD（T－SOD）水平降低（P＜0．05），主要系Mn－SOD水平明显降低所致（P＜0．01），而Cu，Zn－SOD则降低不明显。NO含量的降低与T－SOD活性的降低呈显著的正相关关系（r＝0．3471，P＜0．05）。结论恶性肿瘤患者抗氧化能力下降，氧化与抗氧化作用失衡，机体受过氧化损伤严重。特别是NO作为巨噬细胞免疫效应分子，其水平的低下，是肿瘤细胞逃避免疫监视而发生发展的重要机制之一。
Objective To detect the serum levels of NO, LPO and SOD in 33 patients with gastrointestinal cancer confirmed by pathological examination. Results Compared with chronic superficial gastritis group, the level of NO was significantly lower in patients with malignant tumors (P<0.05), and the level of LPO was significantly higher (P<0.01); the level of total SOD (T-SOD) was decreased (P<0.05). <0.05), mainly due to a significant decrease in Mn-SOD levels (P<0.01), while Cu, Zn-SOD was not significantly decreased. There was a significant positive correlation between the decrease of NO content and the decrease of T-SOD activity (r=0.3471, P<0.05). Conclusion The anti-oxidation ability of patients with malignant tumors is decreased, oxidation and anti-oxidation are unbalanced, and the body is severely damaged by over-oxidation. In particular, NO as a macrophage immune effector molecule, its low level, is one of the important mechanisms for tumor cells to escape from immune surveillance and development.