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目的:观察健脾理气方对肝硬化及癌变的预防作用。方法:以DEN诱发大鼠肝硬化伴癌前期病变为模型,生理盐水为对照。观察项目包括病理形态与生化学指标。结果:用中药后肝纤维化程度减轻;肝细胞增生灶与假小叶减少,肝组织GGT阳性灶和AFP阳性细胞、肝组织Hyp和肝细胞DNA含量均减少;肝组织GGT比活性降低。结论:健脾理气方能同时延缓肝硬化的形成与阻制癌前期的病变,其防癌机制可能在于药物抑制了肝细胞DNA的复制。
Objective: To observe the preventive effect of Jianpi Liqi Recipe on liver cirrhosis and canceration. METHODS: Rat models of cirrhosis with precancerous lesions were induced by DEN. Normal saline was the control. Observation items include pathological and biochemical indicators. Results: The degree of hepatic fibrosis was reduced after the use of Chinese herbs; the hepatocyte proliferation and sham lobule were reduced; the GGT-positive foci and AFP-positive cells in the liver, the liver tissue Hyp and hepatocyte DNA content were reduced; and the liver GGT specific activity was decreased. Conclusion: Jianpi Liqi can delay the formation of liver cirrhosis and prevent the precancerous lesions. The anti-cancer mechanism may be that the drug inhibits the DNA replication of liver cells.