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采用高效液相色谱法比较研究了家兔５－ＦＵ腹腔、静脉和灌胃３种给药途径的药代动力学。结果显示：大剂量腹腔给药能在腹腔、门静脉及肝脏提供高浓度药物，且维持时间长，消除半衰期（ｔ１／２β）分别为（３．８１±０．１４）ｈ和（１．２８±０．０９）ｈ，而周围血药浓度极低；静脉给药后周围血药浓度及门静脉血药浓度均较高，但有效血药浓度维持时间短，ｔ１／２β分别为（０．７１４±０．０２）ｈ和（０．６６８±０．０４）ｈ，灌胃给药后，腹腔液药浓度极低，门静脉血药浓度虽然高于周围血，但吸收不规则，个体差异较大。组织中药浓度测定发现，腹腔给药后，肝脏中药浓度最高，肾脏浓度最低，而静脉给药则肾脏浓度最高。提示：对胃肠道恶性肿瘤术后腹腔内复发和肝转移的防治，腹腔化疗较传统的静脉化疗和口服给药途径为优。
The pharmacokinetics of 5-FU intraperitoneal, intravenous and intragastric administration in rabbits were compared by HPLC. The results showed that high dose of intraperitoneal administration could provide high concentration of drugs in the abdominal cavity, portal vein and liver, and maintained for a long time. The half-life (t1 / 2β) were (3.81 ± 0.14) h and (1.28 ± 0.09) h, while the peripheral plasma concentration was very low. The peripheral plasma concentration and portal vein plasma concentration were higher after intravenous administration, but the effective plasma concentration maintained for a short time with t1 / 2β of (0.714 ± 0.02) h and (0.668 ± 0.04) h. After intragastric administration, the concentration of peritoneal fluid was very low. Although the blood concentration of portal vein was higher than that of peripheral blood, the absorption was irregular and the individual differences were larger. Tissue concentration of Chinese medicine found that, after intraperitoneal administration, the highest concentration of traditional Chinese medicine in the liver, kidney, the lowest concentration, while the highest renal intravenous administration of the highest concentration. Tip: prevention and treatment of postoperative intra-abdominal recurrence and liver metastasis of gastrointestinal cancer, intraperitoneal chemotherapy is superior to traditional intravenous chemotherapy and oral administration.