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加压素是一种有一个氨基酸环的九肽激素,从1954年DuVigneaud等分离和合成加压素以来,早已周知其主要为抗利尿作用。近年来,随着加压素放射免疫测定法的建立、加压素受体的发现和受体拮抗剂的合成,人们对加压素在神经系统作用的认识日趋深刻。研究表明,加压素在脑内有着多种生理和病理效应,许多神经系统疾病的病理生理过程与加压素的变化密切相关。本文就神经系统内加压素的分布、加压素受体及细胞内机制、加压素与神经疾病等几个方面的研究加以综述。一、神经系统内加压素的分布
Vasopressin, a nine-peptide hormone with an amino acid loop, has long been known to predominate as an anti-diuretic effect since isolating and synthesizing vasopressin by DuVigneaud et al. In 1954. In recent years, with the establishment of vasopressin radioimmunoassay, the discovery of vasopressin receptors and the synthesis of receptor antagonists, people’s understanding of the role of vasopressin in the nervous system has become more and more profound. Studies have shown that vasopressin in the brain has a variety of physiological and pathological effects, many of the neurological diseases and pathophysiology of vasopressin changes are closely related. This article reviews the distribution of vasopressin in the nervous system, vasopressin receptors and intracellular mechanisms, vasopressin and neurological diseases. First, the distribution of vasopressin in the nervous system