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本文讨论了儿童中枢神经系统(CNS)的γ-氨基丁酸(GABA)的代谢,尤其着重与儿童临床相关的问题。脑的CABA代谢和功能GABA是一种主要的抑制性神经递质,在CNS中含量高,但不稳定,主要存在于灰质中,酸它在脑内分布和谷氨酸脱羧酶很相似,谷氨脱羧酶是一种兴奋性神经递质,也是一种强调节酶,它需要吡哆酸5-磷酸盐作辅因子,以多分子形式存在于脑内,并具有不同的动力学特性。GABA从中间神经元释放,调节局部脑活性。许多较长的GABA的投射神经元与基底神经节及小脑(Purkinje细胞)相关。GABA通过增强后突触细胞内外之间不同的电位差,发挥对CNS神经元的抑制作用。在去极中,神经元GABA经钙依赖性释放入突触裂隙,在后突触膜,GABA与CNS内不依赖钠的高亲
This article discusses gamma-aminobutyric acid (GABA) metabolism in the child’s central nervous system (CNS), with particular emphasis on clinical issues in children. Cerebral CABA Metabolism and Function GABA is a major inhibitory neurotransmitter that is high but unstable in the CNS and is found mainly in the gray matter. Its distribution in the brain is very similar to glutamate decarboxylase. Valley Ammonia decarboxylase, an excitatory neurotransmitter, is also a stress-regulating enzyme that requires pyridoxine 5-phosphate as a cofactor and exists in the brain as a multi-molecular form with different kinetic properties. GABA is released from interneurons and regulates local brain activity. Projections of many longer GABA neurons are associated with basal ganglia and cerebellum (Purkinje cells). GABA exerts its inhibitory effect on CNS neurons by enhancing different potential differences between the inner and outer synaptic cells. In the depolarization, neuronal GABA is released by calcium-dependent into the synaptic cleft, and in the postsynaptic membrane, GABA and the sodium-independent high-pro in the CNS