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目的利用血氧水平依赖功能磁共振(BOLD-fMRI)成像技术,探讨单侧感音神经性耳聋患者听觉皮层优势半球的变化及可能存在的功能重组。方法选取重度单侧长期感音神经性耳聋患者21例(13例左耳聋,8例右耳聋),采用Sparse设计进行正弦调幅音(AM)任务下的fMRI数据采集,实验刺激为500Hz的载波频率,8Hz的AM,耳聋患者健耳呈现。采用1.5T超导型MRI成像系统,采集脑部的BOLD-fMRI数据后,通过SPM2软件对数据进行统计学分析,得到脑功能活动的图像。结果单侧长期感音神经性耳聋患者健耳给声,双侧听觉皮层均有激活,但仍为对侧半球优势。结论听觉中枢具有可塑性,单侧感音神经性耳聋患者听觉皮层存在着结构重组。
Objective To explore the changes of the dominant hemisphere of auditory cortex in patients with unilateral sensorineural hearing loss and possible functional reorganization by using BOLD-fMRI imaging technique. Methods Twenty-one patients with severe unilateral long-term sensorineural hearing loss (13 cases of left deafness and 8 cases of right deafness) were enrolled in this study. Sparse design was used to acquire fMRI data under the task of sinusoidal amplitude modulation (AM). The experimental stimulation was 500Hz carrier frequency , 8Hz AM, deafness Jianrong presented. 1.5T superconducting MRI imaging system was used to collect the brain BOLD-fMRI data, the data were statistically analyzed by SPM2 software to obtain images of brain function activity. Results Unilateral long-term sensorineural hearing loss in the human ear to sound, both auditory cortex activation, but still contralateral hemispheric advantage. Conclusion The auditory center has plasticity. There is structural remodeling in the auditory cortex of patients with unilateral sensorineural deafness.