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为了研究中国北方儿童结核病与HLAⅠ类基因的关联,我们采用PCR-SSO方法检测了97例北方汉族结核患儿和91例正常对照的HLA-DRBl,DQAl,DQBl等位基因.发现中国北方汉族儿童结核病与HLA-DRBl·1501有显著关联.进一步比较DR分子结构发现β链第86位氨基酸对结核病的易感性可能有重要意义.
To investigate the relationship between childhood tuberculosis and HLA class I genes in northern China, PCR-SSO was used to detect HLA-DRB1, DQA1 and DQB1 alleles in 97 northern Chinese Han children and 91 normal controls. There was a significant association between tuberculosis and HLA-DRB1 · 1501. Further comparison of the molecular structure of DR revealed that the 86th amino acid of β-chain may be of great significance for susceptibility to tuberculosis.