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用于社区防治淋巴丝虫病,理想的药物应是单剂,对微丝蚴和成虫都有效,且没有或极少副作用和不良反应。现在,在伊维菌素和海群生(DEC)的临床试验中,通常是测定不良反应和杀微丝蚴的的效果,但不能直接评估其对成虫的效果。虽然,其杀灭成虫的效果可依据治疗后出现的阴囊结节、长期(1—2年)的微丝蚴被清除以及丝虫抗原的水平等作出推测,但至今还没有敏感而特异的检测成虫死亡的方法。
For community control lymphatic filariasis, the ideal drug should be a single dose of microfilariae and adults are effective, and with little or no side effects and adverse reactions. In clinical trials of ivermectin and seaquot (DEC), the effects of adverse reactions and microfilaria are commonly measured, but their effects on adults are not directly evaluated. Although the effect of killing adult worms can be speculated based on the scrotal nodules that occur after treatment, the long-term (1-2 years) clearance of microfilariae, and the levels of filarial antigens, so far no sensitive and specific tests The method of adult death.