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在某些临床情况下,一定程度的低镁血症可引起室性早搏、定性心动过速、心室颤动和房性心动过速等。镁离子对心肌电生理方面的效应以及心肌细胞动作电位(AP)的研究曾有报道,但多数是在离体和/或与其它离子改变的同时,观察镁离子对心肌AP的影响,结论也不尽一致。为了进一步阐明镁对心肌电生理特性的影响,我们采用浮置玻璃微电极技术,与心电图同步记录豚鼠心室肌AP,观察右心室注射硫酸镁前后AP以及心电图Q-T间期的变化。
In some clinical conditions, a certain degree of hypomagnesemia can cause premature ventricular contractions, tachycardia, ventricular fibrillation and atrial tachycardia. Magnesium ion electrophysiological aspects of the cardiac electrophysiological effects and cardiomyocyte action potential (AP) of the study has been reported, but most of them are in vitro and / or changes with other ions at the same time, observe the impact of magnesium ions on the myocardial AP, the conclusion is also Not consistent. To further elucidate the effect of magnesium on electrophysiological characteristics of myocardium, we used floating glass microelectrode technique to record the AP of guinea pig ventricular muscle synchronously with electrocardiogram and observed the changes of AP and Q-T interval of ECG before and after right ventricular injection of magnesium sulfate.