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心肌组织内 Cu、Fe、Zn、Mg、Ca、Na 和 K 等无机元素含量,与心脏的生理和病理关系甚为密切.已有文献报导在心肌缺血,心机缺血再灌注和异丙基肾上腺素致心脏中毒过程中,心肌的无机元素含量可发生一定的变化,并认为 K 含量改变最为敏感.本研究观察哇巴因中毒时豚鼠心肌组织内上述7种无机元素含量的变化.用3.4×10~(-4)mol/L 的哇巴因,按5μg/(kg·min)恒速由颈外静脉注入豚鼠体内.在出现室性纤维性颤动时处死动物,开胸摘取心脏置于预冷(4℃左右)的去离子水中停搏,挤净心脏残血,去除心内外膜、心脏周围组织和血管;随
The contents of Cu, Fe, Zn, Mg, Ca, Na and K in myocardium are closely related to the physiology and pathology of the heart.It has been reported that in myocardial ischemia, myocardial ischemia-reperfusion and isopropyl Adrenaline-induced cardiotoxicity, the content of inorganic elements in myocardium may change, and that the K content changes the most sensitive.To observe the ouabain poisoning of guinea pig myocardial tissue above seven kinds of inorganic elements in the content of change with 3.4 × 10 ~ (-4) mol / L ouabain was injected into the guinea pig at the constant rate of 5 μg / (kg · min) via the external jugular vein, and animals were sacrificed in the presence of ventricular fibrillation. In the pre-cooling (about 4 ℃) in the de-ionized water arrest, squeeze the heart of residual blood, remove the epicardium, peri-cardiac tissue and blood vessels; with