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目的 :探讨 p16基因和层粘连蛋白在肺癌中的表达及其意义。方法 :用免疫组化法检测 76例肺癌组织、2 0例癌旁组织中 p16基因和层粘连蛋白的表达。结果 :p16基因表达随着肺癌组织学分级的增加阳性率呈下降趋势 ,各组之间有显著性差异 ,而与肺癌淋巴结转移和TNM分期无关。层粘连蛋白表达亦随着肺癌组织学分级的增加阳性率呈下降趋势 ,Ⅰ、Ⅱ级肺癌中的阳性率明显高于Ⅲ级 ,在淋巴结转移组中阳性率显著高于无淋巴结转移组 ,层粘连蛋白表达与肺癌TNM分期无关 ,p16基因和层粘连蛋白表达之间有明显相关性。结论 :p16基因的失活与肺癌的发生有关 ,层粘连蛋白低表达预示着肺癌的低分化和高转移风险 ,p16基因和层粘连蛋白表达之间有明显相关性
Objective: To investigate the expression of p16 gene and laminin in lung cancer and its significance. Methods: The expressions of p16 gene and laminin in 76 cases of lung cancer and 20 cases of paracancerous tissues were detected by immunohistochemistry. Results: The positive rate of p16 gene expression decreased with the increase of histological grade of lung cancer. There was a significant difference between each group, but not with lymph node metastasis and TNM stage of lung cancer. The positive rate of laminin was also decreased with the increase of histological grade of lung cancer. The positive rate of grade Ⅰ and Ⅱ lung cancer was significantly higher than that of grade Ⅲ, and the positive rate in lymph node metastasis group was significantly higher than that in non-lymph node metastasis group The expression of laminin was not related to the TNM stage of lung cancer, and there was a significant correlation between the expression of p16 gene and laminin. CONCLUSIONS: The inactivation of p16 gene is associated with the development of lung cancer. The low expression of laminin indicates the risk of poorly differentiated and metastatic lung cancer. There is a significant correlation between the expression of p16 gene and laminin