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引言对地中海贫血的治疗和后天的预防,目前尚无有效措施,因而防止病儿出生,原则上是预防该病的唯一有效方法。为此目的,首要条件是将患有该病的年青人鉴别出来,然后继之以遗传学宣传和产前诊断。但由于多数发病地区此项工作尚未受到重规,故作者积40年研究之经验介绍这种简单、迅速、耗费甚低的普查筛选方法。方法作者有计划地对拉齐奥地区在校学习最后一年的中学生进行检查(13—14年龄组)。第一步检查:研究每例血标本的(a)红细胞形态,并作(b)红细胞渗透脆性试验。 (a)检查红细胞形态须在现制的、未污染的血涂片上进行。涂片时应使红细胞清
Introduction There is currently no effective treatment for thalassemia and acquired prevention, so preventing the birth of sick children is, in principle, the only effective way to prevent the disease. To this end, the first condition is to identify young people who have the disease, followed by genetic counseling and prenatal diagnosis. However, since most of the endemic areas have not been heavily regulated in this work, the author’s 40-year research experience introduces this simple, rapid and inexpensive screening screening method. Methods The authors systematically inspected secondary school students in Lazio’s final year of study (13-14 age group). First Check: Study the (a) erythrocyte morphology for each sample of blood and make (b) a test for erythrocyte infiltration fragility. (a) Check the morphology of erythrocytes to be performed on an existing, uncontaminated blood smear. Smear red blood cells should be cleared