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目的 :探讨胃癌不同TNM分期患者和不同分化患者血清可溶性CD4(SCD4)、可溶性CD8(SCD8)浓度的变化。方法 :采用酶联免疫吸附方法中的双抗体夹心法测定胃癌患者 (63例 )及正常对照 (36例 )、胃炎患者 (31例 )和癌前病变患者 (胃炎伴不典型增生 ,8例 )血清SCD4和SCD8浓度。结果 :血清SCD4和SCD8浓度随正常 -胃炎 -癌前病变-胃癌而逐级升高。血清SCD4、SCD8浓度与胃癌TNM分期和胃癌分化程度均不相关 (P >0 .0 5 )。结论 :血清SCD4和SCD8浓度的测定对探讨胃癌患者免疫状态的变化有一定意义。
Objective: To investigate the changes of serum soluble CD4 (SCD4) and soluble CD8 (SCD8) levels in patients with gastric cancer with different TNM stages and different differentiations. Methods: Gastric cancer patients (63 cases) and normal controls (36 cases), gastritis patients (31 cases) and precancerous lesions (gastritis with atypical hyperplasia, 8 cases) were detected by enzyme linked immunosorbent assay. Serum SCD4 and SCD8 concentrations. Results: Serum levels of SCD4 and SCD8 increased gradually with normal-gastritis-precancerous lesions-gastric cancer. Serum levels of SCD4 and SCD8 were not correlated with TNM stage and gastric cancer differentiation (P> 0.05). Conclusion: The determination of serum SCD4 and SCD8 levels has certain significance in exploring the changes of immune status in patients with gastric cancer.