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为探讨老年性记忆减退的机制，将老年大鼠分为老年记忆减退组（简称老年减退组）和老年记忆正常组（简称老年正常组）。用免疫细胞化学、组织化学双标技术定量分析内侧隔核-斜角带（SM－DB）中神经生长因子受体（NCFR）和NADPH-d阳性神经元的数量、其结果是：老年减退组大鼠和老年正常组大鼠相比较，SM、斜角带垂直支（vDB）、水平支（hDB）中的NGFR／NADPH－d双重反应阳性、NGFR单独反应神经元数也呈明显下降；NADPH－d单独反应阳性神经元的数量也较老年正常组减少（P＜0．05）。相关分析表明，受试大鼠逃避潜伏期与双重反应阳性神经元、NGFR和NADPH-d单独反应阳性神经元的数量呈明显负相关。提示SM－DB的三类神经元都参与了老年记忆减退的机制，但以NGFR阳性神经元的损害起主要作用。
To investigate the mechanism of senile memory loss, the aged rats were divided into the elderly memory impairment group (referred to as the elderly decline group) and the elderly normal memory group (the elderly normal group). The numbers of nerve growth factor receptor (NCFR) and NADPH-d positive neurons in medial septal nucleus-skeletal strips (SM-DB) were quantified by immunocytochemistry and histochemical double labeling. The results were as follows: NGFR / NADPH-d dual positive reaction was observed in SM, vDB and hDB in rats compared with normal aged rats, and the number of neurons in NGFR alone was significantly decreased. NADPH The number of -d solitary reactive neurons also decreased compared with the normal group (P <0.05). Correlation analysis showed that there was a significant negative correlation between the escape latency and the number of NGFR and NADPH-d single reactive-positive neurons in the double-reactive neurons. It is suggested that all three neurons of SM-DB participate in the mechanism of senile memory loss, but play a major role in the damage of NGFR-positive neurons.