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目的：检测膀胱移行细胞癌中增殖细胞核抗原（ＰＣＮＡ）的表达，探讨与膀胱移行细胞癌预后的关系。方法：应用免疫组织化学技术，检测５５例膀胱移行细胞癌ＰＣＮＡ的表达。结果：５５例膀胱移行细胞癌中，ＰＣＮＡ标记指数随病理分级增高和肿瘤体积增大而增高，Ⅰ、Ⅱ、Ⅲ级间均有非常显著差异（Ｐ＜ ０．０１）。ＰＣＮＡ标记指数高表达者死亡率明显高于低表达者（Ｐ＜ ０．０１）。结论：ＰＣＮＡ是判断膀胱移行细胞癌恶性程度和预后的一个重要标志。
Objective: To detect the expression of proliferating cell nuclear antigen (PCNA) in transitional cell carcinoma of the bladder and to investigate the relationship with the prognosis of bladder transitional cell carcinoma. Methods: Immunohistochemical technique was used to detect the expression of PCNA in 55 cases of bladder transitional cell carcinoma. Results: In 55 cases of transitional cell carcinoma of the bladder, the index of PCNA increased with the increase of the pathological grade and the volume of the tumor. There was a significant difference between the grades Ⅰ, Ⅱ and Ⅲ (P <0.01). The mortality rate of PCNA marker index in high expression was significantly higher than in low expression (P <0.01). Conclusion: PCNA is an important marker for judging the malignant degree and prognosis of transitional cell carcinoma of the bladder.