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我们对28例婴儿痉挛症患者分二组给予激素或硝基安定单一治疗,分别观察其临床疗效及脑电图的改变,并进行对照比较.1一般资料28例中男18例,女10例,发病年龄3～11月,原发性19例,症状性9例(其中缺氧一缺血性脑病7例,苯丙酮酸尿症2例).临床表现均符合婴儿痉挛症的三联症:痉挛性发作、智力减退、脑电图呈高峰节律紊乱.17例选用激素治疗,其中10例用ACTH治疗,剂量2u/kg.d,静脉滴注14天,尔后肌注14天,共28天后逐渐减量停药;7例用强的松口服治疗,剂量2mg/kg.d,3～4周后逐渐减量停药.11例用硝基安定口服治疗,剂量0.5ing/kg.d.均在治疗2～4周判断临床疗效及复查脑电图.
28 cases of infantile spasms in patients with sub-two groups were given hormone or nitrazepam monotherapy, respectively, to observe the clinical efficacy and changes in EEG, and compared with the control .1 General Information 28 males and 18 females, 10 females , Age of onset from March to November, 19 cases of primary, 9 cases of symptomatic (including 7 cases of hypoxic-ischemic encephalopathy, 2 cases of phenylketonuria) Clinical manifestations are in line with infantile spasms of triad: Spastic seizures, mental retardation, EEG peak rhythm disorder .17 cases of hormone therapy, of which 10 cases were treated with ACTH, dose 2u / kg.d, intravenous infusion of 14 days, after 14 days of intramuscular injection, a total of 28 days The patients were treated with prednisone orally, and the dose was 2mg / kg.d, which was gradually reduced after 3 to 4 weeks, and 11 patients were treated with nitrazepam orally at the dose of 0.5ing / kg.d. In the treatment of 2 to 4 weeks to determine the clinical efficacy and review EEG.