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化学消毒、灭菌剂的历史有三个重要阶段。第一是在1920年使用甲醛溶液,也是最早使用的消毒剂之一;第二是1930年后发现了环氧乙烷;嗣后,Pepper等(1963年)为探寻新消毒剂,在双醛类化合物筛选中发现乙二醛、丙二醛、丁二醛及戊二醛有很好的杀芽胞作用,其中尤以戊二醛最强。此后,戊二醛作为消毒剂的研究和应用的报道不断增多。碱性戊二醛水溶液是国外十年来广泛使用的消毒剂之一,多用于医院与实验室消毒。世界卫生组织病毒性肝炎科学小组的报告推荐使用戊二醛作为病毒性肝炎污染器械和物品的消毒。因其优点较多,使用范围正在逐渐扩大。
There are three important stages in the history of chemical disinfection and sterilization agents. The first was the use of a formaldehyde solution in 1920, and was one of the earliest disinfectants used. The second was the discovery of ethylene oxide after 1930. Subsequently, Pepper et al. (1963), in search of a new disinfectant, Glyoxal, malondialdehyde, succinaldehyde and glutaraldehyde were found to have a good sporicidal effect in compound screening, especially glutaraldehyde. Since then, glutaraldehyde as a disinfectant research and application of increasing reports. Alkaline glutaraldehyde aqueous solution is one of the disinfectants widely used in foreign countries over the past decade, more for hospital and laboratory disinfection. The WHO viral hepatitis team recommended the use of glutaraldehyde as a disinfectant for viral hepatitis contaminated equipment and articles. Because of its advantages, the use of the area is gradually expanding.