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1974年海南岛发现首例抗氯喹恶性疟，海南建省前1987年疟疾发病率为23．4，恶性疟占34．8％．病例数为5267例，流行区人口50余万。建省后进一步增加投入，加强防治研究：（1）掌握了抗氯喹恶性疟流行病学的新特点，适时调整防治措施；（2）筛选出几种抗疟药联用新方案，用于临床治疗和现场防治；（3）在全省主要疟区推广控制抗氯喹恶性疟的“毛阳模式”。疟疾发病率自1989年起逐年下降，1996年降至历史最低水平为5．30，恶性疟占24．3％，病例数为1026例，比1987年下降80％，流行区人口缩减了一半，防治成效显著。
Hainan Island in 1974 found the first case of chloroquine-resistant falciparum malaria, Hainan Province before the establishment of the province in 1987 the incidence of malaria was 23.4, 34.8% of falciparum malaria. The number of cases was 5267 cases, the population of more than 50 million pop. (1) Grasp the new characteristics of the epidemiology of the anti-chloroquine falciparum malaria and timely adjust the prevention and control measures; (2) Screen out several new antimalarial combination programs for the clinical Treatment and on-site prevention and treatment; (3) Promote the “Mao-Yang Model” for controlling chloroquine-resistant falciparum malaria in the major malaria endemic areas in the province. The incidence of malaria has been declining year by year since 1989, dropping to a historical low of 5.30 in 1996 and 24.3% of cases of falciparum malaria. The number of cases was 1026 cases, down 80% from 1987 and the population in the epidemic zone was reduced by half. Prevention and treatment achieved remarkable results.