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Reavens于1988年首次提出了胰岛素抵抗综合征(IRS)的概念,认为胰岛素抵抗是诸多致动脉粥样硬化危险因素的基本原因,最终导致动脉粥样硬化的形成和发展。高胰岛素血症是胰岛素抵抗的一种代偿表现或治疗后表现,往往与心血管疾病的危险因素(如低高密度脂蛋白胆固醇血症、高三酰甘?
Reavens first proposed the concept of insulin resistance syndrome (IRS) in 1988, arguing that insulin resistance is the primary cause of many atherogenic risk factors that eventually lead to the development of atherosclerosis. Hyperinsulinemia is a compensatory manifestation of insulin resistance or post-treatment performance, often associated with cardiovascular risk factors (such as low-density lipoprotein cholesterol,