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为了解运动神经诱向因子１（ＭＮＴＦ１）及其受体在人胎盘发育过程中可能的功能意义，用ＭＮＴＦ１单克隆抗体及抗独特型单克隆抗体在不同发育阶段人胎盘绒毛石蜡切片上进行免疫组织化学反应，并结合图像分析技术观察了ＭＮＴＦ１及其受体在不同发育阶段人胎盘绒毛上的变化。结果显示，在胎盘绒毛的发育过程中，ＭＮＴＦ１及其受体的相对含量呈周龄性变化，妊娠早期（孕６～９周），随周龄的增加而增加，于９周时达到峰值，此后于妊娠中期及妊娠晚期则随周龄的增加而降低。以上结果提示：（１）ＭＮＴＦ１对绒毛滋养层细胞ｈＣＧ的合成和分泌可能有促进作用，而且此作用是通过其受体介导而实现的；（２）ＭＮＴＦ１对胎儿的生长发育可能也有一定作用。
To understand the possible functional significance of MNTF1 and its receptor in human placenta development, MNTF1 monoclonal antibodies and anti-idiotypic monoclonal antibodies were used to immunize human placenta paraffin sections at different developmental stages Histochemical reaction, and combined with image analysis techniques observed MNTF1 and its receptors in different developmental stages of human placental changes in hair. The results showed that during the process of placental villus development, the relative content of MNTF1 and its receptors showed a weekly age change. During the first trimester of gestation (from 6 to 9 weeks of gestation), the relative content of MNTF1 and its receptors increased with the increase of age and reached the peak at 9 weeks. Since then in the second trimester and third trimester of pregnancy with the increase of the age decreased. The above results suggest that: (1) MNTF1 may promote hCG synthesis and secretion in villous trophoblast cells, and this effect is mediated through its receptor; (2) MNTF1 may also play a role in fetal growth and development .