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目的:研究葡萄糖转运蛋白-1(GLUT-1)、肿瘤坏死因子-α(TNF-α)在非小细胞肺癌(NSCLC)组织中的表达及临床意义。方法:应用免疫组化方法检测100例NSCLC组织和24例良性肿瘤组织中TNF-α、GLUT-1的表达,并分析其与临床病理特点之间及两者相互关系。结果:NSCLC组织中的GLUT-1、TNF-α蛋白阳性率明显高于良性肿瘤组织(P<0.05)。TNF-α组:晚期组织(Ⅲ)明显高于中、早期(Ⅱ、Ⅰ)组织(P<0.05),有淋巴结转移组织明显高于无淋巴结转移组织(P<0.05),N2组明显高于N1组(P<0.05)。GLUT-1组:中低分化组织明显高于高分化组织(P<0.05),有淋巴结转移组织明显高于无淋巴结转移组织(P<0.05),N2组明显高于N1组(P<0.05)。GLUT-1与TNF-α的表达呈正相关。结论:TNF-α、GLUT-1在NSCLC组织中的过表达与肺癌的生长、侵袭转移有密切关系,联合两者的检测有助于判断NSCLC的转移、分期。
Objective: To investigate the expression and clinical significance of GLUT-1 and TNF-α in non-small cell lung cancer (NSCLC). Methods: The expressions of TNF-α and GLUT-1 in 100 cases of NSCLC and 24 cases of benign tumor were detected by immunohistochemistry. The relationship between them and the clinicopathological features and their relationship were analyzed. Results: The positive rates of GLUT-1 and TNF-α in NSCLC tissues were significantly higher than those in benign tumor tissues (P <0.05). The level of TNF-α in advanced stage (Ⅲ) was significantly higher than that in middle stage and early stage (Ⅱ, Ⅰ) (P <0.05), and the level of lymph node metastasis was significantly higher in non-lymph node metastasis group N1 group (P <0.05). In the GLUT-1 group, the moderately and poorly differentiated tissue was significantly higher than that in the well-differentiated tissue (P <0.05), and the lymph node metastasis was significantly higher in the GLUT-1 group than in the non-lymph node metastasis group (P <0.05) . There was a positive correlation between the expression of GLUT-1 and TNF-α. Conclusion: The overexpression of TNF-α and GLUT-1 in NSCLC tissues is closely related to the growth, invasion and metastasis of lung cancer. The combination of both could be helpful in judging the metastasis and staging of NSCLC.