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基础和临床研究表明,急性痛和慢性痛能激活岛叶皮层的神经元,并且抑制岛叶神经元的兴奋性产生镇痛作用。本文主要关注岛叶神经元参与神经病理性痛的细胞和分子机制。主要研究内容和结果:(1)建立小鼠腓总神经结扎(CPN)神经病理性痛模型。神经损伤的小鼠,触诱发痛行为在3天开始出
Basic and clinical studies have shown that acute pain and chronic pain can activate the neurons of the island cortex and inhibit the excitability of the island neurons to produce analgesic effects. This article focuses on the cellular and molecular mechanisms involved in the involvement of insular neurons in neuropathic pain. Main research contents and results: (1) To establish the neuropathic pain model of mouse common peroneal nerve ligation (CPN). Nerve-damaged mice, tactile allodynia started out in 3 days