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大量研究资料证明,胆固醇虽非冠心病的唯一病因,但两者间确存在着因果关系。例如:许多种动物饲以大量胆固醇后发生动脉粥样硬化;高胆固醇血症猴(或其他一些动物)发生从脂纹而至溃疡斑块等一系列动脉内膜病变;用药物或饲料降低弥猴血中胆固醇水平,并持续一定时间,上述病理过程逆转;临床上见到儿童时期仅高胆固醇血症,并无其他危险因素参与,亦可能死于严重早发性冠心病;流行病学研究观察到世界不同地区的人群中,血中胆固醇水平与冠心病发病率直接相关;主动脉、冠状动脉上隆起的斑块数及其严重程度与血浆胆固醇水平强相关;一些前瞻性研究反映健康人血浆胆固醇水平预示着日后可能发生冠心病的危险程度。
A large number of research data show that, although the only cause of cholesterol is not coronary heart disease, but there is indeed a causal relationship between the two. For example, many animals suffer from atherosclerosis after consuming large amounts of cholesterol; hypercholesterolemia monkeys (or some other animals) develop a series of arterial intimal lesions ranging from greasy lines to ulcerated plaques; Monkey blood cholesterol levels, and continued for some time, the reversal of the pathological process; clinically seen only childhood hypercholesterolemia, no other risk factors involved, may also die of severe early coronary heart disease; epidemiological studies It is observed that blood cholesterol levels are directly related to the incidence of coronary heart disease in different regions of the world. The number of plaques and their severity in the aorta and coronary arteries are strongly correlated with plasma cholesterol levels. Some prospective studies have shown that healthy subjects Plasma cholesterol levels indicate the degree of risk of coronary heart disease in the future.