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目的评价放射性核素89锶(89Sr)在前列腺癌骨转移中的治疗效果和不良反应。方法观察前列腺癌骨转移并伴有不同程度骨痛患者66例,使用89SrCl2静脉注射治疗,观察其镇痛效果、骨转移灶的变化、前列腺特异性抗原(PSA)及不良反应等。结果66例患者接受89Sr治疗后,止痛的总有效率达89.4%(59/66),无效10.6%(7/66),骨转移灶有明显减少。对PSA有不同程度的下降。所有治疗者均未发现严重的不良反应和毒副作用。结论89Sr治疗前列腺癌骨转移疼痛效果明显,对前列腺癌骨转移灶亦有治疗作用,是一种安全有效的方法。
Objective To evaluate the therapeutic effect and adverse reactions of 89Sr (89Sr) in bone metastasis of prostate cancer. Methods Sixty-six patients with bone metastasis of prostate cancer accompanied with varying degrees of bone pain were treated with 89SrCl2 intravenous injection. The analgesic effects, changes of bone metastases, PSA and adverse reactions were observed. Results The total effective rate of analgesia was 89.4% (59/66) in 66 patients after receiving 89Sr treatment, 10.6% (7/66) was ineffective, and the bone metastases were obviously decreased. PSA to varying degrees of decline. No serious adverse reactions and side effects were found in all the patients. Conclusion 89Sr treatment of prostate cancer bone metastases pain obvious effect on prostate cancer bone metastases also have a therapeutic effect is a safe and effective method.