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目的探讨草酸的联合白细胞介素Ⅱ治疗恶性胸腔积液的临床疗效。方法对40例恶性肿瘤伴恶性胸腔积液患者行胸腔置管并沿导管向胸腔内注入草酸铂150mg及白细胞介素Ⅱ400万单位,据胸水量治疗2-4次,观察积液量的变化及不良反应。结果在40例病例中,CR 23例,占57.5%;PR 13例,占32.5%。总有效率(CR+PR)达90%,NC 4例,占10%。其中胸腔内治疗2次达到CR12例,治疗4次达到CR11例,且无明显不良反应。结论草酸铂可以联合白细胞介素Ⅱ腔内置药用于临床恶性胸腔积液的治疗。
Objective To investigate the clinical efficacy of oxalic acid combined with interleukin Ⅱ in the treatment of malignant pleural effusion. Methods Forty patients with malignant tumor with malignant pleural effusion underwent thoracic catheterization and catheterized into the thoracic cavity with 150 mg of oxaliplatin and 24 million of interleukin - Adverse reactions. Results Among the 40 cases, CR was 23 (57.5%) and PR 13 (32.5%). The total effective rate (CR + PR) reached 90%, NC 4 cases, accounting for 10%. Which intrathoracic 2 times to CR12 cases, 4 times to CR11 cases, and no significant adverse reactions. Conclusion Oxaliplatin can be used in combination with interleukin Ⅱ intracavitary for the treatment of clinical malignant pleural effusion.