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目的:分析2007～2010年南京地区19家综合性三级和二级医院鲍曼不动杆菌(Ab)抗感染药物使用趋势,为评价临床合理用药提供依据。方法:根据限定日剂量(DDD)计算7类15种抗菌药物的用药频度,采用SPSS17.0软件对用药趋势进行线性回归分析。结果:三级医院碳青霉烯类、喹诺酮类、哌拉西林/他唑巴坦用药频度(DDDs/1 000)呈增长趋势,头孢哌酮/舒巴坦呈减少趋势;二级医院碳青霉烯类、四环素类、头孢菌素类、舒巴坦和他唑巴坦酶抑制剂用量均为增长趋势;19家医院碳青霉烯类、四环素类、哌拉西林/他唑巴坦及抗菌药物总用药频度为增长趋势。三级医院平均每半年所有抗菌药物用药频度均大于二级医院,仅环丙沙星小于二级医院。结论:19家医院每种和总碳青霉烯类、哌拉西林/他唑巴坦和总抗菌药物用药频度显著增加,需加强本地区感染控制以及抗菌药物临床合理应用。
OBJECTIVE: To analyze trends in the use of anti-infectives of Acinetobacter baumannii (Ab) in 19 general tertiary and secondary hospitals in Nanjing from 2007 to 2010 to provide evidence for clinical rational drug use. Methods: According to the defined daily dose (DDD), the frequency of medication of seven classes of 15 kinds of antibacterials was calculated, and the linear regression analysis of medication tendency was carried out by SPSS17.0 software. Results: The dosage of carbapenems, quinolones and piperacillin / tazobactam in tertiary hospitals showed a trend of increasing trend while the rate of cefoperazone / sulbactam showed a decreasing trend. The level of carbon Penem, tetracyclines, cephalosporins, sulbactam and tazobactam enzyme inhibitors were increasing trend; 19 hospitals carbapenems, tetracyclines, piperacillin / tazobactam And the total frequency of antimicrobial drugs for the growth trend. The average frequency of all antimicrobial drugs in Grade III hospitals was greater than that in Grade II hospitals every six months, and only ciprofloxacin was less than Grade II hospitals. CONCLUSIONS: The frequency of administration of each and every combination of carbapenems, piperacillin / tazobactam, and total antimicrobial agents in 19 hospitals increased significantly, and infection control in the region and the clinical rational use of antimicrobial agents need to be strengthened.