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目的:通过观察血清CRP水平、TCD血流速度改变以及NIHSS评分来探讨丁苯酞与纤溶酶联用治疗急性后循环梗死的疗效。方法:急性后循环梗死患者52例,随机平均分成2组,治疗组加用丁苯酞与纤溶酶,对照组加用纤溶酶,治疗14 d。计算治疗前、后NIHSS评分值,检测血清C反应蛋白(CRP)浓度并应用TCD检测并记录基底动脉(BA)平均血流速度(Vmv),对比分析组各指标。结果:治疗前两组患者各指标对比分析,差异无显著性(P>0.05),两组各指标进行治疗前后对比,NIHSS评分及血清CRP水平降低,BA平均血流速度值增高,差异有统计学意义(P<0.05),治疗14 d后,治疗组变化较对照组显著,差异有统计学意义(P<0.05)。结论:丁苯酞能显著降低血清CRP浓度,减轻炎性反应,提高病区血管血流速度,与纤溶酶联合治疗急性后循环梗死,疗效更佳,推荐用于急性后循环梗死患者的救治。
OBJECTIVE: To evaluate the efficacy of butylphthalide in combination with plasmin in the treatment of acute posterior circulation infarction by observing serum CRP levels, changes in TCD blood flow velocity and NIHSS score. Methods: Fifty-two patients with acute posterior circulation infarction were randomly divided into two groups. Butyphthalide and plasmin were used in the treatment group and plasmin was used in the control group for 14 days. The NIHSS scores before and after treatment were calculated. The serum C-reactive protein (CRP) levels were measured. The mean basilar artery (BA) blood flow velocity (Vmv) was measured and recorded by TCD. Results: There was no significant difference between the two groups before and after treatment (P> 0.05). Before and after treatment, NIHSS score, serum CRP level decreased and BA mean blood flow velocity increased (P <0.05). After 14 days of treatment, the changes in the treatment group were significantly more significant than those in the control group (P <0.05). CONCLUSION: Butylphthalide can significantly reduce serum CRP concentration, reduce inflammatory reaction, and improve blood flow velocity in the ward. Combined with plasmin, it is more effective in treating acute posterior circulation infarction. It is recommended for the treatment of patients with acute posterior circulation infarction .