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目的:评价甲硝唑与制霉菌素治疗滴虫性阴道炎患者的疗效及其对血清炎性因子水平的影响。方法:选取2014年1月—2015年10月间收治的滴虫性阴道炎患者81例,采用随机分组法将其分为对照组40例和治疗组41例;比较两组患者治疗后的总有效率、不良反应的发生率及Hs-CRP、IL-8、IL-2测得值的改善情况。结果:治疗组治疗后的总有效率为95.12%高于对照组为75.00%(P<0.05),Hs-CRP、IL-8、IL-2测得值优于对照组(P<0.05);治疗组患者用药期间不良反应的发生率为2.20%低于对照组为10.00%(P>0.05)。结论:采用甲硝唑与制霉菌素治疗滴虫性阴道炎患者,疗效显著,明显改善了血清炎性因子水平。
Objective: To evaluate the curative effect of metronidazole and nystatin in the treatment of trichomonas vaginitis and its influence on serum inflammatory factors. Methods: Totally 81 patients with trichomonas vaginitis were selected from January 2014 to October 2015. The patients were divided into control group (40 cases) and treatment group (41 cases) by randomization method. The incidence of adverse reactions, and the improvement of Hs-CRP, IL-8, IL-2. Results: The total effective rate of treatment group was 95.12% higher than that of control group (75.00%) (P <0.05). The measured values of Hs-CRP, IL-8 and IL-2 were better than those of control group (P <0.05). The incidence of adverse reactions in the treatment group was 2.20% lower than that in the control group (P> 0.05). Conclusion: The treatment of trichomonas vaginitis with metronidazole and nystatin significantly improved the serum inflammatory cytokines.