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给大鼠气管内一次滴注博莱霉素,观察肺部炎症及其修复形成肺纤维化的过程.滴注后第7、21天,可见肺系数及肺组胺含量显著升高。第21天时还有血清丙二醛含量显著升高,而此时肺羟脯氨酸含量无明显改变。提示为亚急性炎症阶段。第60天时,肺羟脯氨酸含量显著升高,表明有肺纤维化形成。764-3治疗可显著缓解博莱霉素所致的上述指标的变化。提示764-3可防止博莱霉素所致肺炎症及其随后发展成肺纤维化。这一作用除直接与其对抗早期的炎症过程有关外,尚不能排除直接地抗纤维化作用。
The rats were intratracheally instilled bleomycin once, to observe the inflammation of the lungs and repair process of formation of pulmonary fibrosis.On the 7th and 21st days after instillation, the pulmonary coefficient and lung histamine content were significantly increased. On the 21st day there was also a significant increase in the serum MDA level, but at this time there was no significant change in the content of lung hydroxyproline. Tips for the subacute stage of inflammation. On day 60, lung hydroxyproline levels were significantly elevated, indicating pulmonary fibrosis. 764-3 treatment can significantly alleviate the bleomycin-induced changes in these indicators. Tip 764-3 prevents bleomycin-induced lung inflammation and its subsequent development into pulmonary fibrosis. In addition to being directly related to its role in combating early inflammatory processes, it is not yet possible to rule out direct anti-fibrotic effects.