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目的：探讨短程化疗期间抗结核药物的毒副反应。方法对2010年到2013年在我院确诊并应用抗结核药物治疗的600例患者进行回顾性分析。结果短程化疗期间使用抗结核药物共有254发生毒副反应，其中胃肠道症状、肝损害[1-3]、发热、白细胞减少、尿酸升高等发生较多，其毒副反应多发生在抗结核治疗2月内。结论了解抗结核药物毒副反应发生的时间、种类和处理方式，可帮助及时、有效的判断是何种药物引起的毒副反应，调整抗结核治疗方案，保证抗结核治疗顺利完成；同时还可及时发现一些较为严重的毒副反应，避免加重。现将观察结果报告如下。“,”Purpose:The paper aims to discuss the side effects of antituberculosis drugs used for short course chemotherapy. Method By making a retrospective analysis on 600 patients who have been diagnosed as tuberculosis and have used the antituerculosis drugs for treatment in our hospital for the past three years(2010-2013). Result 254 patients have side effects mainly include gastrointestinal symptoms, liver damage, fever, leucopenia, and higher uric acid. The side effects ofter appear after the patients use antituberculosis drugs for about two months. Conclusion We can promptly and effectively make out the very drug which has caused the side effects, adjust our treatment method,making sure the treatment going on smoothly, and timely find some severe side effects by recording the time when side effect kind, and the handing method. The fol owing is the investigation result.