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60年代初期口服避孕药(OC)已在世界范围内被广泛使用,从60年代后期就开始报告OC可以产生高血压的问题,80年代对此又进行了全面估价。血压升高是心血管病的危险因素,所以该问题受到心血管和计划生育研究者的广泛重视。本文对这一问题作一简要综述。一、OC是否导致高血压?:据报告OC致高血压发生率17%,平均为4～5%。一个涉及8万妇女的前瞻性对照研究认为:所有服用雌孕激素复方口服避孕药(COC)6个月以上都将引起血压升高。服OC 5年后, 在用药前血压正常的妇女中,收缩压平均升高12.3mmHg,舒张压平均升高8mmHg,这不是一种罕见的特异质反应,而是服含雌激素OC超过半年的妇女中所共有的用药反
The early 60s oral contraceptives (OC) has been widely used around the world, from the late 60s began to report the problem of OC can produce high blood pressure, in the 1980s and conducted a comprehensive evaluation. High blood pressure is a risk factor for cardiovascular disease, so the issue is widely recognized by cardiovascular and family planning researchers. This article gives a brief overview of this issue. First, whether OC causes high blood pressure?: It is reported that the incidence of OC caused by hypertension 17%, with an average of 4 to 5%. A prospective, controlled study of 80,000 women concluded that all patients taking a combination of estrogen and progestogen-derived oral contraceptives (COCs) for more than 6 months will cause elevated blood pressure. OC 5 years after taking clothes in the normotensive women before treatment, systolic blood pressure increased by an average of 12.3mmHg, diastolic blood pressure increased by an average of 8mmHg, this is not a rare special reaction, but taking estrogen-containing OC more than six months Women share the same medication