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本文应用激素放免测定方法以232例正常催乳素分泌及189例正常促性腺激素分泌为对照,观测了各类高催乳素血症198例,各类低催乳素血症191例,儿童组34例,老年组130例,口服长效避孕药9例及高催乳素血症并行 LHRH 兴奋试验者14例。测垂体 PRL,LH,FSH 水平,以研究不同催乳素水平对垂体促性腺激素的影响,及高催乳素血症时垂体对 LHRH 的反应性。结果提示:无论高催乳素或低催乳素血症80%以上的受试者血清催乳素与血清促性腺激素分泌水平呈负相关关系,即高催乳素血症抑制垂体促性腺功能,反之亦然。高催乳素血症时垂体对外源 LHRH 反应迟顿或完全受抑。催乳素的分泌对垂体促性腺激素分泌及生殖功能的调控具有重要的影响和作用。
In this study, 232 cases of normal prolactin secretion and 189 cases of normal gonadotropin secretion were used as controls in this study. 198 cases of various types of hyperprolactinemia, 191 cases of various types of low prolactinemia, 34 cases of children , 130 elderly patients, oral long-acting contraceptives in 9 cases and hyperprolactinemia LHRH excited in 14 cases. Pituitary PRL, LH, FSH levels were measured in order to study the effects of different prolactin levels on pituitary gonadotropin and pituitary response to LHRH in hyperprolactinemia. The results suggest that serum prolactin is negatively correlated with serum gonadotropin secretion in over 80% of patients with hyperprolactinemia or hypoprotetremia, ie, hyperprolactinemia inhibits pituitary gonadotropin and vice versa . Hyperprolactinemia pituitary response to exogenous LHRH late or completely inhibited. Prolactin secretion of pituitary gonadotropin secretion and reproductive function regulation has an important impact and role.