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目的探讨复方斑鳌注射液联合化疗治疗老年晚期胃癌患者的疗效。方法老年晚期胃癌患者共60例,随机分为观察组及对照组,每组30例,两组患者给予相同的化疗方案,观察组在此基础上加用复方斑蝥注射液(100 ml/次,静脉注射,第1~10天)。接受2个周期治疗后,评价患者的疗效,采用KPS评分评价患者的生活质量,并比较两组的不良发应发生率。结果观察组与对照组患者均顺利完成2个周期的化疗,且效果可评价。观察组实体瘤完全缓解(CR)、实体瘤部分缓解(PR)、实体瘤未发生明显变化(SD)、实体瘤进一步发展(PD)分别为0、16、9、5例,有效率(RR)53.33%;对照组分别为0、10、12、8例,RR 33.33%,两组差异有统计学意义(χ~2=13.071,P<0.05)。观察组中生活质量改善者(KPS评分≥80分)5例(16.67%),稳定者16例(53.33%),对照组分别为2(6.67%)、7例(23.33%),两组生活质量改善率和稳定率差异均有统计学意义(χ~2值分别为6.184、16.071,P均<0.05)。观察组患者中不良反应的发生率(56.67%)低于对照组(90.00%),差异有统计学意义(χ~2=17.451,P<0.05)。结论复方斑蝥注射液联合化疗治疗老年晚期胃癌可显著提高短期治疗效果,减少及减轻化疗过程中的不良反应,显著改善患者生活质量。
Objective To investigate the curative effect of compound Acuola injection combined with chemotherapy on elderly patients with advanced gastric cancer. Methods A total of 60 elderly patients with advanced gastric cancer were randomly divided into observation group and control group, with 30 cases in each group. The two groups were given the same chemotherapy regimen. The observation group was given compound cantharidin injection (100 ml / Intravenous injection, days 1 to 10). After two cycles of treatment, the patients were evaluated for their efficacy, KPS was used to assess the quality of life of the patients, and the incidence of adverse reactions was compared between the two groups. Results Both the observation group and the control group were successfully completed two cycles of chemotherapy, and the effect can be evaluated. In the observation group, the complete remission (CR) of solid tumors, partial remission of solid tumors (PR), no significant changes of solid tumors (SD), and the further development of solid tumors (PD) were 0, ) Were 53.33%. There were 0, 10, 12, and 8 cases in the control group, and the RR was 33.33%. There was a significant difference between the two groups (χ ~ 2 = 13.071, P <0.05). In the observation group, 5 cases (16.67%) had improvement in quality of life (KPS score≥80 points), 16 cases (53.33%) were stable and 2 cases (6.67%) and 7 cases (23.33% The difference of quality improvement rate and stability rate were statistically significant (χ ~ 2 values were 6.184,16.071, P <0.05). The incidence of adverse reactions in the observation group (56.67%) was lower than that in the control group (90.00%), the difference was statistically significant (χ ~ 2 = 17.451, P <0.05). Conclusion Compound cantharidin injection combined with chemotherapy for advanced gastric cancer can significantly improve the short-term treatment effect, reduce and reduce adverse reactions during chemotherapy, and significantly improve the quality of life of patients.