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目的:了解广州地区孕产妇对人类微小病毒B19(HPV-B19)的易感性、感染率及母胎垂直传播等情况,指导HPV-B19病毒相关疾病的诊治及优生优育工作。方法:采用聚合酶链式反应技术PCR对1257例孕产妇静脉血、142例HPV-B19阳性孕产妇分娩的胎儿脐血和126例正常人静脉血进行HPV-B19基因检测。结果:孕产妇感染率为25.3%,明显高于正常对照组的感染率(3.2%)(P<0.05),同时,142例阳性孕产妇分娩的胎儿脐血中均检测出HPV-B19基因。结论:检测结果提示孕产妇对HPV-B19有易感性,其感染率为25.3%,并且HPVB19感染存在母胎垂直传播的情况,HPV-B19病毒可自由地通过胎盘屏障,进入羊膜腔,可致胎儿先天性感染,引起胎儿子宫内死亡、习惯性流产、胎儿水肿和贫血。
Objective: To understand the maternal sensitivity to human parvovirus B19 (HPV-B19), infection rate and vertical transmission of maternal mothers in Guangzhou area and to guide the diagnosis, treatment and prenatal and postnatal care of HPV-B19 related diseases. Methods: Polymerase chain reaction (PCR) was used to detect HPV-B19 gene in 1257 pregnant women with venous blood, 142 fetuses with umbilical cord blood and 126 healthy controls. Results: The infection rate of pregnant women was 25.3%, which was significantly higher than that of the control group (3.2%) (P <0.05). Meanwhile, HPV-B19 gene was detected in cord blood of 142 pregnant women who gave birth. Conclusion: The results suggest that pregnant women are susceptible to HPV-B19 with an infection rate of 25.3%. HPV-B19 infection has vertical transmission of the mother’s fetus. The HPV-B19 virus freely passes through the placental barrier and enters the amniotic cavity, causing fetal Congenital infection, causing fetal intrauterine death, habitual abortion, fetal edema and anemia.