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作者对一种新型的重组人-αB/D干扰素(rHu IFN-αB/D)的抗病毒能力进行了研究.在培养14天的人单个核细胞中,rHu IFN-αB/D明显地抑制了1型单纯疱疹病毒(HSV-1/VR3)的复制及其对细胞的破坏作用,其抑制效果比同剂量rHu IFN-αA或IFN-γ好.用HSV-1/VR3鼻内感染小鼠后
The authors investigated the antiviral ability of a novel recombinant human-αB / D interferon (rHu IFN-αB / D), which significantly inhibited rHu IFN-αB / D in human mononuclear cells cultured for 14 days The HSV-1 / VR3 replication and its cytotoxicity against HSV-1 / VR3 were much better than those of the same dose of rHu IFN-αA or IFN-γ. Mice were infected with HSV-1 / VR3 intranasally Rear