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目的 :观察前列腺素 E1 (PGE1 )对慢性阻塞性肺疾病 (COPD)急性加重期患者的疗效。方法 :对 2 5例 COPD的患者在常规治疗的基础上加用 PGE1 10 0～ 2 0 0︼g/ d,对照组仅接受常规治疗。结果 :PGE1 治疗组患者临床症状和体征改善的有效率明显高于对照组 ;治疗组治疗后肺功能 (FEV1 .0 )有明显改善 (P<0 .0 1) ,但对照组改善不明显 (P>0 .0 5 ) ;2组患者治疗后血气分析各项指标 (p H、Pa O2 、Pa CO2 、Sa O2 )均有一定程度的改善 (P<0 .0 5或 P<0 .0 1) ,治疗组改善程度明显高于对照组 (均为 P<0 .0 1)。结论 :PGE1 对 COPD急性加重期的患者有一定疗效。
Objective: To observe the efficacy of prostaglandin E1 (PGE1) in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods: Twenty-five patients with COPD were treated with PGE1 10 0 ~ 20 0︼g / d on the basis of routine treatment, while the control group received routine treatment only. Results: The effective rate of clinical symptoms and signs improvement in PGE1 treatment group was significantly higher than that in control group. The pulmonary function (FEV1. 0) in treatment group was significantly improved (P <0.01), but the improvement in control group was insignificant P> 0.05). After treatment, the blood gas analysis indexes (p H, Pa O2, Pa CO2, Sa O2) in both groups improved to a certain degree (P <0.05 or P < 1), the treatment group improved significantly higher than the control group (all P <0 01). Conclusion: PGE1 has some curative effect on patients with acute exacerbation of COPD.